Volume 45, Number 1 (January - February 2000)

Key words:  determination of 2-thiouracil and its derivatives, iodimetry, potentiometric titration

The iodimetric determination of 2-thiouracil and its derivatives in alkaline medium is presented. In the volumetric titration  with the potentiometric end-point detection the determinability range is 100-1000 mmol for 2-thiouracil, 30-700 mmol for 6-amino-2-thiouracil, 60-500 mmol for 5-carbethoxy-2-thiouracil and 100-500 mmol for 5-methyl-2-thiouracil. The relative standard deviation was below 1% in all determinations. The elaborated method was applied to the determination of 6-propyl-2-thiouracil in drugs.