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Volume 46, Number 6
(November - December 2001) |
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Volume 46, Number 6
(November - December 2001) |
Determination of Carbimazole with the Use of the Iodine-Azide Reaction
by Witold Ciesielski, Robert Zakrzewski and Monika Skowron
Department of Instrumental Analysis, University of Lodz, 3 Lindleya Street, 90-131 Lodz, Poland
Key words: 1-ethoxycarbonyl-3-methyl-2-thio-4-imidazoline, carbimazole, coulometric titration, iodine-azide reaction, thin-layer chromatography
The methods of determination of carbimazole involving iodine-azide reaction
are presented. In volumetric titration the range of determination is 120-720
nmol (30-180 ml). In coulometric titration using
biamperometric indicator system the range of determination is 2.0-20.0
nmol (20-200 ml). In chromatographic analysis
the detection limit is 0.08 nmol for TLC and 0.04 nmol for HPTLC. The volumetric
titration was applied to determination of carbimazole in tablets. The iodine-azide
reagent was applied to detection of carbimazole in blood serum. The detection
limit of carbimazole in blood serum is 0.15 nmol (75 ml).
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