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Volume 46, Number 6
(November - December 2001) |
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Volume 46, Number 6
(November - December 2001) |
Spectrofluorimetric Determination of Cetirizine Hydrochloride in Pharmaceutical Preparations
by M.B. Melwanki, J. Seetharamappa, B.G. Gowda and A.G. Sajjan
Department of Chemistry, Karnatak University, Dharwad - 580 003, India
Key words: spectrofluorimetry, cetirizine hydrochloride, pharmaceutical analysis
A rapid and simple fluorimetric procedure for the determination of trace
amounts of cetirizine hydrochloride in pharmaceutical formulations has
been developed. The measurement of the fluorescence intensity was performed
at 297 nm after excitation at 230 nm. The fluorescence intensity is a linear
function of concentration of cetirizine hydrochloride up to 16 mg
ml-1. The detection limit was found to
be 0.31 ng ml-1.
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