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Course description:
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The course is addressed mainly to students choosing specialization in Physical and Organic Chemistry interested in understanding the experimental techniques and application of modern Nuclear Magnetic Resonance spectroscopy (NMR). There are considered basic principles of NMR, basic elements of pulse sequences and the rules of their construction which should allow one to understand and analyze the most routine NMR spectroscopy experiments in chemistry. The important role of NMR in investigation of biomolecules in the field of fast developing experimental methods is indicated. The problem of sensitivity of NMR spectroscopy is considered in relation to features of nuclei of interest and chosen experimental techniques. The multidimensional (correlation) experiments and their applications in chemistry and biochemistry are discussed with relation to: measurement sensitivity, signal assignments, and determination of scalar and dipolar coupling constants. Additionally, the principles and examples diffusion measurements and imaging techniques are given.
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