Third Microsymposium of the "International Scholarship Program for Graduate Studies in Faculty of Chemistry, University of Warsaw - From simple molecules to nanostructured and bioactive materials" October 6 - 8th, 2011, Palace in Łochów, Poland
Chronicle
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Thursday Oct. 6th 18:15 - 18:45 – Urszula Kulesza Design and synthesis of 1α,25-dihydroxyvitamin D3 analogues modified at C-9 The active form of vitamin D3, hormone 1α,25-dihydroxyvitamin D3, controls the metabolism of calcium and phosphorous and plays an important role in regulation of the cell cycle. Therefore, a variety of clinical applications of 1α,25-(OH)2-D3 would be possible, for example for the treatment of osteoporosis, psoriasis, autoimmune diseases and some types of cancer (breast, colon, prostate, leukemia, etc.). However, the calcemic effects induced by 1α,25-(OH)2-D3 limit the use of the natural hormone for such clinical purposes. The aim of the research is the design of convenient and efficient synthetic route to the analogues of 1α,25-dihydroxyvitamin D3 characterized by novel structural modifications in position 9, with a hope of obtaining compounds possessing selective antiproliferative activity and low calcemic effect. 9-Methyl-, 9-methylene- and 19-nor-9-methylene-substituted analogues of 1α, 25-dihydroxyvitamin D3 have been synthesized. 
Discussion 
End of afternoon session 
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