Third Microsymposium of the "International Scholarship Program for Graduate Studies in Faculty of Chemistry, University of Warsaw - From simple molecules to nanostructured and bioactive materials" October 6 - 8th, 2011, Palace in Łochów, Poland
Chronicle
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Friday Oct. 7th 15:00 - 15:30 - Katarzyna Jodko-Piórecka Biomembrane interactions of catecholamines and an α-tocopherol analogue: Significance for their antioxidant activity. Catecholamines might behave as endogenous phenolic antioxidants protecting the neuronal tissue from deleterious effects of oxidative stress. The understanding of the mechanism of their antioxidant action and possible interplay with other antioxidants in lipid membranes requires interdisciplinary research on the kinetics and thermodynamics of antioxidant(s)/membrane interactions. Herein, I report kinetic data that, as a prerequisite, verify the antioxidant activity of catecholamines by measuring their scavenging activity against peroxyl radicals in a heterogeneous lipid/water system and give evidence about the synergistic effect between catecholamines and PMHC. I also present results from experiments on the interaction between catecholamines, PMHC and model lipid membranes by microcalorimetry (Differential Scanning Calorimetry and Isothermal Titration Calorimetry). The calorimetric studies were performed on unilamellar vesicles assembled from 1,2dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and 1,2-dimyristoyl-sn-glycero-3-phosphoglycerol (DMPG) as model lipid membranes. 
Discussion 
Prof. Gary J. Blanchard - Friday's afternoon session Chairman 
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