Urszula Kulesza

Synthesis of novel 1α,25-dihydroxyvitamin D₃ analogs with unnatural triene system

Urszula Kulesza, UW
Supervisor: prof. Rafał Siciński (UW)

1α,25-Dihydroxyvitamin D₃ [1α,25-(OH)₂D₃], known also as calcitriol, is the most potent metabolite of vitamin D₃. Calcitriol is a hormonal form responsible for calcium and phosphorus homeostasis and it is involved in a wide array of other physiological processes, for example, cell differentiation and proliferation. Such a broad spectrum of activities makes low-calcemic analogs of calcitriol potentially useful in various biomedical applications.
We have designed and synthesized analogs of 1α,25-dihydroxyvitamin D₃ with the unnatural triene moiety, “rotated” around C2 axis in comparison with the natural hormone, as well as yet unknown 9-alkylated calcitriol. These newly obtained vitamins are interesting candidates for structure-activity studies. The biological testing of the synthesized compounds is underway.

Chairman - prof. Zbigniew Floriańczyk

Discussion