Information for foreign students


UNIWERSITY OF WARSAW

1 Pasteura Str., 02-093 Warsaw, Poland, phone: +48 (0)22 822 02 11

38


Subject

Principles of Asymmetric
Transformations


No / course unit code


Semester

2M

Type of course

Specialization Lecture


Teaching hours
 per semester    per week

30      2

ECTS credits

3


Lecturer:

Prof. dr. hab. Zbigniew Czarnocki
Room: 228     Phone extn.:215     email: czarnoz@chem.uw.edu.pl

Teaching Division:

Organic Chemistry

Educational and
professional goals:


Acquiring the knowledge of basic concepts of modern optical activation methods.

Course description:

This course is designed to survey the fundamental principles of molecular asymmetry in biological and synthetic organic chemistry. Topics include properties of stereoisomers and properties of racemates and their enantiomeric components. Stereoisomers discrimination in achiral and chiral envirionment. Biodiscrimination. Enzymatic reactions. Origin of enantiomeric homogenity in nature and the origin of life. Concepts of non-conservating of parity in modern physics and its consequences in chemistry. Absolute asymmetric synthesis. Asymmetric transformations of racemates. Resolution of stereoisomers. Enantiomeric and diastereomeric enrichment and kinetic resolution. Racemization mechanisms and applications. Basic concepts of stereoselective synthesis (Hammond postulate and Curtin-Hammett principle). Models for chirality transfer. Thermodynamic and stereoelectronic effects in stereodifferentiation. Selected examples of stereoselective synthesis.

Literature:
E.L. Eliel, S.H. Wilen, "Stereochemistry of Organic Compounds", John Wiley & Sons, New York, 1994.

Required background:


General Chemistry, Organic Chemistry I, Stereochemistry.

Form of assessment:


Exam

Remarks:

Recommended for students planning to pursue further studies in organic and biological chemistry.




Supervisor: Jadwiga Skupinska

Webmaster: Adam Myslinski