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Educational and
professional goals:
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The students attending the course will get essential knowledge about the structure of organic free radicals, their physical and chemical properties, the experimental methods of studies of free radical reaction kinetics, and the role of free radicals in a number of chemical and biochemical processes. The aim of the course is to prepare the students to read scientific literature on free radicals as well as to conduct the research projects in this field.
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Course description:
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History of organic free radical chemistry. Structure of free radicals. Carbon-, oxygen-, nitrogen-, and sulfur-centered free radicals. Production of free radicals in laboratory. Detection of free radicals. Stability and reactivity. Physical organic chemistry methods used for studying of free radical reaction mechanisms: thermodynamics, thermochemistry, and chemical kinetics. Kinetic Isotope Effects. Oxidation and reduction mediated by free radicals. Gaseous and liquid phase processes. Solvation of radicals and the Cage Effect. Kinetic Solvent Effect. Examples of decomposition, fragmentation, cyclization, transformation and recombination processes. Free radicals in organic synthesis. Atmospheric processes mediated by free radicals. Toxicology of free radicals - a few cases of reactions in living organisms. Metal ions as precursors of free radicals. Oxidative stress. Examples of diseases caused by free radicals. Free radical theory of aging.
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