Research Experience
- 2012-now: Senior NMR Project Manager, C4X Discovery Ltd., Manchester, UK
- determined 4D-structures of molecules in context of drug design
- 2011-2012: Research Associate, Laboratory of Molecular Interactions, Faculty of Chemistry, Warsaw University, Warsaw, Poland
Supervisor: Professor Wiktor Kozminski
- determined Bacillus subtilis Lipase A structure using 4D non-uniformly sampled NMR spectra
- 2008-2010: Senior Scientist, Max-Planck-Institut fur Kohlenforschung, Mulheim an der Ruhr, Germany
Supervisor: Professor Manfred T. Reetz
- studied Bacillus subtilis Lipase A thermostability using NMR spectroscopy, X-ray crystallography, circular dichroism and enzymatic assays
- 2005-2008: Research Associate, Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA
Supervisor: Professor Kurt Wuthrich
- determined protein structures with NMR spectroscopy
- analyzed protein data bases using bioinformatics
- 2004-2005: Research Assistant, Laboratory of Peptides, Faculty of Chemistry, Warsaw University, Warsaw, Poland
- studied mechanism of action of tyrosine phenol-lyase
- 2004-2005: Volunteer Researcher, Department of Biophysics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
Supervisor: Dr. Igor Zhukov
- interpreted NMR spectra of s100A1 and e1 (C-terminal domain) proteins
- 1999-2004: Ph.D. Student, Laboratory of Peptides, Faculty of Chemistry, Warsaw University, Warsaw, Poland
Supervisor: Professor Marianna Kanska
- designed, developed and optimized new routes of syntheses of stereospecifically labeled aromatic amino acids
- elaborated methods of determination of kinetic isotope effects, and used them in the studies on L-tyrosine phenol lyase
- discovered and proved details of the mechanism of action of L-tyrosine phenol lyase
- 1999-2002: Volunteer Researcher, Department of Genetics, Faculty of Biology, Warsaw University, Warsaw, Poland
Supervisor: Dr. Piotr Borsuk
- studied polymorphism of mammals’ insulin C-peptide
- 2001: Socrates-Erasmus Program Student, Department of Organic Chemistry, Radboud University of Nijmegen, Nijmegen, The Netherlands.
Supervisors: Professor Floris P. J. T. Rutjes, Christien Schortinghuis
- synthesized substituted prochiral malonodinitriles, and analysed products of their enzymatic hydrolyses
- synthesized 5-13C labeled 3-hydroxy-5-cyanobutyramide, and studied mechanism of its enzymatic racemisation using 13C-NMR
- 1999-2000: Volunteer Researcher, Department of Biophysics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
Supervisor: Dr. Aleksandra Wyslouch-Cieszynska
- synthesized peptides on solid phase support: phosphorylated and non-phosphorylated fragment of human eIF4E, Hodges helix derivatives, marinostatin D
- 1997-1999: M.Sc. Student, Laboratory of Peptides, Faculty of Chemistry, Warsaw University, Warsaw, Poland
Supervisor: Professor Marianna Kanska
- synthesized 14C labeled L-phenylalanines, and used them for determination of kinetic isotope effects in the reaction catalysed by L-phenylalanine ammonia lyase
- 1997-1999: Volunteer Researcher, Department of Molecular Biology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Poland
Supervisor: Professor Tadeusz Kulikowski
- synthesized 5-methyluridine, its 5’-monophosphate, and their derivatives
research grants
- 2009-2010: EU-NMR initiative of European Commission: NMR Studies of Lipase Thermostability
- 2002-2004: State Committee for Scientific Research Ph.D. Grant 4 T09A 039 23: Syntheses of isotopomers of L-tyrosine and their use in studies of the mechanism of action of beta-tyrosinase. Execution evaluated as excellent.